Menetrier Disease

• rare, idiopathic hypertrophic gastropathy
• patients usually present with epigastric pain and hypoalbuminemia (from loss of albumin into the gastric lumen)
• bimodal age distribution
• childhood form thought to be linked to cytomegalovirus infection
• diagnosis is made by combination of endoscopic and radiologic findings
• Upper GI series: thickened, lobulated folds in the gastric fundus which trap barium; hypersecretion may dilute barium which may prevent mucosal coating
• CECT: thickening of mucosa and submucosa which projects into the gastric lumen
• differential diagnosis
• Zollinger Ellison Syndrome - rugal fold thickening is not as pronounced, gastric ulcers, pancreatic involvement
• Gastritis - thickened folds usually in the antrum, H. pylori positive
• Lymphoma - thickened folds due to soft tissue masses not due to edema

REFERENCES
Friedman J, Platnick J, Farruggia S, et al. Menetrier Disease. Radiographics 2009;29:297-301.

Kanne JP,