Enlarged parietal foramina are considered a benign normal variant in calvarial ossification. They are associated with anomalies of cerebral venous development, variations in occipital cortical infolding, scalp defects, and cleft palate. Although sometimes palpable, these defects are usually discovered incidentally. For patients with prominent foramina, cerebral vascular imaging may be considered for work up of aforementioned anomalies.
Fink AM and Maixner W. Enlarged parietal foramina: MR imaging features in the fetus and neonate. AJNR 2006;27:1379-81.
Reddy AT, Hedlund GL, Percy AK. Enlarged parietal foramina: association with cerebral venous and cortical anomalies. Neurology 2000;54(5):1175-8.