Cortical Nephrocalcinosis

• Acute cortical necrosis: Most common cause. Can be due to severe acute hypotension, drugs (amphoteracin), or toxins (antifreeze).
• Chronic glomerulonephritis: Second most common cause. Can be due to diabetes, lupus, or membranous glomerulonephritis.
• Chronic transplant rejection:
  
  
• Oxalosis: Due to altered bile metabolism from small bowel pathology (e.g., Crohn disease) or small bowel resection.
• Alport syndrome: Associated with hereditary nerve deafness. Rare cause of cortical nephrocalcinosis.
• Sickle cell anemia: Rare cause of cortical nephrocalcinosis.

References

Dyer RB, Chen MY, Zagoria RJ. Abnormal calcifications in the urinary tract. Radiographics. 1998 Nov-Dec;18(6):1405-24.