Drug | Effect | Comment |
Insulin | Similar to the effect of eating close to FDG administration. Will also cause diffuse increase in muscle uptake and a decrease in liver uptake. |
|
Bezafibrate | Fibrate drug used for hyperlipidemia. |
|
Benzodiazepines | ||
Levothryoxine | ||
Metformin | Shown above. Increases colonic FDG uptake and can result in a competitive decrease in cardiac FDG uptake. |
In addition to the above, certain patient factors can increase cardiac FDG uptake: Male gender, younger patients (< 30 years), fasting duration of <5 hours, and patients with heart failure tend to have higher cardiac FDG uptake.
References
- Israel O, Weiler-Sagie M, Rispler S, Bar-Shalom R, Frenkel A, Keidar Z, Bar-Shalev A, Strauss HW. PET/CT quantitation of the effect of patient-related factors on cardiac 18F-FDG uptake. J Nucl Med. 2007 Feb;48(2):234-9.
- Maurer AH, Burshteyn M, Adler LP, Steiner RM. How to differentiate benign versus malignant cardiac and paracardiac 18F FDG uptake at oncologic PET/CT. Radiographics. 2011 Sep-Oct;31(5):1287-305.
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