Synovial, clear cell, and alveolar soft part sarcomas were previously thought to have high rates of lymph node metastases, but this has not found to be the case in larger case series.
The sarcomas that account for the most lymph node metastases due to their relatively higher prevalence are leiomyosarcoma and pleomorphic undifferentiated sarcoma (formerly malignant fibrous histiocytoma).
Regional lymph node involvement is a poor prognostic factor. In addition, patients with isolated regional lymph node involvement at diagnosis have a poorer outcome than patients who develop isolated regional lymph node involvement later in the course of their disease.
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