Wednesday, May 18, 2011

The Pulvinar Sign

The Pulvinar sign refers to T2 hyperintensity in the posterior thalamic nuclei (the pulvinar). It is most sensitive for variant Creutzfeldt-Jakob disease. A positive pulvinar sign can be called when the pulvinar are hyperintense to the anterior putamina.

Differential considerations include bilateral thalamic infarctions, perinatal ischemic injury, deposition of iron or copper, and neoplasm (e.g., lymphoma, glioma).

T1 hyperintensity in the same area is seen in Fabry disease.

Images of the pulvinar sign can be found at AJNR and AJR.


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