Myocardial Uptake on Bone Scan

Myocardial uptake on nuclear medicine bone scan can be seen in the following conditions:

• Long-standing congestive heart failure:
• Myocardial infarction: Focal localization to calcium hydroxyapatite from local tissue necrosis or damage.
• Unstable angina: Patchy uptake is seen.
• Pericarditis:
• Amyloidosis: Abnormal extracellular deposition of protein. Important to note because cardiac involvement indicates a worse prognosis. ^99mTc phosphate binds to calcium-binding sites of amyloid.
• Hyperparathyroidism:
• Postresuscitation/cardiac contusion:
• Post defibrillation:
• Cardiomyopathy: Diffuse uptake.
• Pericardial tumor: Diffuse uptake.

References

• Fard-Esfehani A, Assadi M. Myocardial Tc-99m MDP Uptake on the Bone Scintigraphy in the Hemodialysis-Associated Amyliodosis (an incidental finding). Alasbimn Journal. 2005; 8(30): AJ30-7.
• Gentili A, Miron SD, Bellon EM. Nonosseous accumulation of bone-seeking radiopharmaceuticals. Radiographics. 1990 Sep;10(5):871-81.
• Janowitz WR, Serafini AD. Intense myocardial uptake of 99mTc-diphosphonate in a uremic patient with secondary hyperparathyroidism and pericarditis: case report. J Nucl Med. 1976 Oct;17(10):896-8.
• Kida T, Hujita Y, Sasaki M, Inoue J. Myocardial and vascular uptake of a bone tracer associated with secondary hyperparathyroidism. Eur J Nucl Med. 1986;12(3):151-4.
• Love C, Din AS, Tomas MB, Kalapparambath TP, Palestro CJ. Radionuclide bone imaging: an illustrative review. Radiographics. 2003 Mar-Apr;23(2):341-58.