Wednesday, March 10, 2010

Yamaguchi Criteria of Adult-Onset Still Disease

Presence of 5 or more criteria, at least 2 of which are major yields a 96% sensitivity and 92% specificity for adult-onset Still disease.

Major Criteria
  • Temperature of >39°C for >1 wk
  • Leukocytosis >10,000/mm3 with >80% PMNs
  • Typical rash
  • Arthralgias >2 wk
Minor Criteria
  • Sore throat
  • Lymph node enlargement
  • Splenomegaly
  • Liver dysfunction (high AST/ALT)
  • Negative ANA, RF


Yamaguchi M, Ohta A, Tsunematsu T, Kasukawa R, Mizushima Y, Kashiwagi H, Kashiwazaki S, Tanimoto K, Matsumoto Y, Ota T, et al. Preliminary criteria for classification of adult Still's disease. J Rheumatol. 1992 Mar;19(3):424-30.

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