The rim sign is very specific (up to 100%) and has a high positive predictive value (up to 100%) for complicated acute cholecystitis (ulceration, necrosis, fibrous exudation, perforation, empyema, or gangrene). Unfortunately, its sensitivity and negative predictive value are only 45% and 39%, respectively.
Because of its high specificity and positive predictive value for complicated acute cholecystitis, it has been suggested that 2- to 4-hour delayed images for excluding chronic cholecystitis can be skipped when the rim sign is present with nonvisualization of the gallbladder.
Special thanks to Jon Sweany for corrections.
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