Friday, December 10, 2010

Arthritis and Primary Biliary Cirrhosis

Patients with primary biliary cirrhosis may present with an erosive arthropathy distributed in the distal and proximal interphalangeal joints with relative sparing of the metacarpophalangeal joints. These marginal erosions vary from small, punched-out lesions to large defects with sparing of the articular surface. Cartilage loss and joint space narrowing can also be seen.

Chondrocalcinosis, which is seen with liver disorders such as hemochromatosis and Wilson disease can also be seen. Hypertrophic osteoarthropathy is a rare complication.

The picture may be complicated by coexistent rheumatoid arthritis.

References

O'Connell DJ, Marx WJ. Hand changes in primary biliary cirrhosis. Radiology. 1978 Oct;129(1):31-5.

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