Wednesday, October 13, 2010

Chemical Shift Characterization of Adrenal Masses

Several methods can be used to help differentiate adrenal adenomas from malignant adrenal neoplasms. These include signal intensity index (SII) and adrenal-to-spleen ratio (ASR), among others. These are calculated from chemical shift images using the signal intensity (SI) of the adrenal gland on in-phase images (SIAi), the SI of the adrenal gland on opposed-phase images (SIAo), and the signal intensity (SI) of spleen (SIS) on in-phase (i) and opposed-phase (o) images. The liver, which was once used as a reference organ, is not a good comparison, because it can lose signal on opposed-phase images when there is fatty infiltration.

The SII seems to be the most reliable method. All adrenal adenomas had values > 16.5% and all metastatic tumors had a value < 11.2%. An adrenal-to-spleen ratio of less than 0.71 indicates a lipid-rich adenoma. Mnemonic for the ASR formula: O (opposed-phase) Over i (in-phase).

Chemical shift imaging has a sensitivity of ~80%-100% for the differentiation of adrenal lesions, and a specificity of ~90%-100%. No significant difference exists between CT and chemical shift imaging for characterizing lipid-rich adenomas; however, chemical shift imaging may be better for evaluating lipid-poor adenomas with attenuation of up to 30 HU.

False negatives can occur with adenomas with relatively lipid-poor, compact cells. False positives in metastases (renal cell carcinoma, hepatocellular carcinoma, liposarcoma, well-differentiated adrenal cortical carcinoma) that contain fat or envelop periadrenal fat.

Equations made with the online LaTeX equation editor.

References

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