A discordant nodule may represent benign lesions such as follicular adenoma/adenomatous hyperplasia or, in a small number of cases, thyroid cancer.
A patient with a hot nodule on 99mTc-pertechnetate imaging should get a 24-hour iodine scan.
Tuesday, July 6, 2010
Discordant Thyroid Nodule
A thyroid nodule is considered discordant if it is hot on 99mTc and cold on 24-hour iodine imaging. Since 99mTc-pertechnetate is trapped but not organified, whereas iodine is both trapped and organified, a discordant nodule may either represent 1) reduced organification of iodine, or 2) rapid turnover of organified iodine.
A discordant nodule may represent benign lesions such as follicular adenoma/adenomatous hyperplasia or, in a small number of cases, thyroid cancer.
A patient with a hot nodule on 99mTc-pertechnetate imaging should get a 24-hour iodine scan.
A discordant nodule may represent benign lesions such as follicular adenoma/adenomatous hyperplasia or, in a small number of cases, thyroid cancer.
A patient with a hot nodule on 99mTc-pertechnetate imaging should get a 24-hour iodine scan.
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