Epidermal inclusion cysts are common lesions of the skin, but relatively uncommon in the breast. They are filled with lamellated keratin formed through inclusion of keratinizing squamous epithelium within the dermis. The typical appearance is a smooth, round nodule attached to the skin.
On mammography, they appear as circumscribed lesions and may have calcifictions. On ultrasound, they are solid, circumscribed, and complex with extension into the dermis (seen in the grayscale image of patient A). An onion-ring appearance with alternating concentric hyperechoic and hypoechoic rings corresponding to multiple layers of keratin has also been described.
Malignant transformation is rare, but excision is recommended by some.
References
Crystal P, Shaco-Levy R. Concentric rings within a breast mass on sonography: lamellated keratin in an epidermal inclusion cyst. AJR Am J Roentgenol. 2005 Mar;184(3 Suppl):S47-8.
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