Tuesday, March 20, 2012

Infradiaphragmatic Brown Fat Uptake

Brown fat uptake in FDG-PET is usually fairly characteristic in the neck, shoulder and costovertebral regions: bilateral, symmetric, intense uptake that is usually multifocal although linear uptake is also possible.

Infradiaphragmatic brown fat uptake poses a challenge when asymmetrical or focal, and may be mistaken for adrenal malignancy or misregistration due to respiration. Correlation with PET images shows the uptake to be located in infradiaphragmatic fat.


  • Bar-Shalom R, Gaitini D, Keidar Z, Israel O. Non-malignant FDG uptake in infradiaphragmatic adipose tissue: a new site of physiological tracer biodistribution characterised by PET/CT. Eur J Nucl Med Mol Imaging. 2004 Aug;31(8):1105-13.
  • Reddy MP, Ramaswamy MR. FDG uptake in brown adipose tissue mimicking an adrenal metastasis: source of false-positive interpretation. Clin Nucl Med. 2005 Apr;30(4):257-8.

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