Testing for molybdenum breakthrough is usually done by placing the eluate in a lead shield and using a commercial dose calibrator whose energy is set to that of 99Mo photons(740 keV and 780 keV).
Saturday, December 12, 2009
Molybdenum Breakthrough
Molybdenum breakthrough refers to contamination of 99mtechnetium obtained by elution of a molybdenum-99 column. The 99mTc generated must be tested for molybdenum before administration to patients. The US Nuclear Regulatory Commission (NRC) allow no more than 0.15 μCi of 99Mo per 1 mCi of 99mTc at the time of administration. The last part is important. Because the half life of 99Mo is longer than that of 99mTc (66 hours vs 6 hours), if you let the eluate sit around, the relative concentration of 99Mo will rise, making it unusable.
Testing for molybdenum breakthrough is usually done by placing the eluate in a lead shield and using a commercial dose calibrator whose energy is set to that of 99Mo photons(740 keV and 780 keV).
Testing for molybdenum breakthrough is usually done by placing the eluate in a lead shield and using a commercial dose calibrator whose energy is set to that of 99Mo photons(740 keV and 780 keV).
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