Splenic Uptake on Bone Scan

Splenic uptake on bone scan is thought to be related to microscopic or macroscopic calcium deposition or due to high concentrations of phosphatase enzyme systems. Splenic uptake on bone scan can be seen with:

• Blood dyscrasias: Sickle cell disease is the most common etiology for splenic uptake on bone scan. A shrunken spleen is typical in adults, but the spleen may be normal in size in children.
• Subcapsular hematoma:
• Hemochromatosis:
• Glucose-6-phosphate dehydrogenase deficiency:
• Metastatic disease:
• Splenic hemangioma:
• Splenic artery calcification:

References

Yapar AF, Aydin M, Reyhan M. Diffuse splenic Tc-99m MDP uptake in hypersplenic patient. Ann Nucl Med. 2004 Dec;18(8):703-5.