Tumor Margin Differential Diagnosis

• IA: Geographic with sclerotic border (non-aggressive, benign)
• IB: Geographic without sclerotic border (non-aggressive)
• IC: Geographic with wide zone of transition (Aggressive)
• II/III: Moth-eaten/permeative (Aggressive)

	IA	IB	IC	II/III
Brodie abscess	X
Benign Fibrous Histiocytoma of Bone	X
Non-ossifying fibroma	X
Osteoid osteoma	X
Chondroblastoma	X	X
Enchondroma (inactive)	X	X
Fibrous dysplasia	X	X
Aneurysmal bone cyst	X	X	X
Chondromyxoid fibroma	X	X	X
Giant cell tumor		X	X
Enchondroma (active)			X
Chondrosarcoma	LG		X
Langerhans cell histiocytosis	X		X	X
Myeloma/metastasis		X	X	X
Brown tumor			X	X
MFH/fibrosarcoma			X	X
Osteomyelitis			X	X
Osteosarcoma			X	X
Ewing				X
Round cell tumors				X
LG, low-grade

References

• Musculoskeletal Radiology: The Requisites, 3rd edition, p 408.
• AFIP 2009-2010 syllabus, pp 812-814.