Intrahepatic Peripheral Cholangiocarcinoma: Path Issue

Cholangiocarcinoma is an adenocarcinoma that affects the bile ducts from the terminal ductules to the ampula. Intrahepatic peripheral cholangiocarcinoma (IPC) may be mistaken for colon cancer metastases on pathology. A primary colon cancer, therefore, should be excluded when cholangiocarcinoma is suspected. This is especially important in patients with ulcerative colitis, who are at risk for both colon cancer and cholangiocarcinoma.